一、个人简介

李华，男，中共党员，博士，教授，硕士研究生导师，山东动物学会理事。2015年6月毕业于555000Jc线路检测中心动物学专业，2015年9月工作至今。承担《分子生物学》等本科生课程和《现代分子生物学技术》等研究生课程的教学；主要从事天然免疫机制方面的研究工作，主持省厅级项目2项、横向课题1项，共发表SCI论文17篇。

二、研究方向

1、鱼类天然免疫模式识别受体的鉴定及抗病机理研究。

2、小鼠炎症性肠炎和肠癌的发病机制研究。

三、承担项目

1.NLRP3炎症小体在乳腺癌细胞中的激活及其在PI3K-Akt信号通路介导的癌细胞浸润转移中的作用研究，山东省自然科学基金，2017.08-2019.12，主持。

2.NLRP3在PI3K-Akt信号通路介导的乳腺癌细胞浸润转移中的抑制作用研究，山东省高等学校科技计划项目，2017.01-2018.12，主持。

3.黄鳝抗细菌病感染的免疫学基础,国家重点研发计划子课题，2018.12-2022.12，参与。

四、教学科研成果（论文、专著、专利等）

1.Yaoyao Zhu#, Shijuan Shan#, Huaping Zhao, Rongrong Liu, Hui Wang, Xinping Chen, Guiwen Yang*, Hua Li*, Identification of an IRF10 gene in common carp (Cyprinus carpio L.) and analysis of its function in the antiviral and antibacterial immune response, BMC Vet Res. 2020,16(1):450.

2.Hua Li, Hui Wang, Wujun Wen, Guiwen Yang*, The antioxidant system inSuaeda salsaunder salt stress, Plant Signal Behav. 2020,15(7):1771939.

3.Zhu Y#, Shan S#, Feng H, Jiang L, An L, Yang G*, Li H*, Molecular characterization and functional analysis of interferon regulatory factor 9 (irf9) in common carp Cyprinus carpio: a pivotal molecule in the Ifn response against pathogens. J Fish Biol. 2019, 95(2):510-519.

4.Miao Yin, Ying Zhang, Hua Li*, Advances in Research on Immunoregulation of Macrophages by Plant Polysaccharides, Frontiers in Immunology, 2019, 10: 145.

5.Ting Li#, Lei Wang#, Yonghuan Zhang, Xinyi Guo, Xinze Chen, Fumiao Zhang, Guiwen Yang, Wujun Wen* and Hua Li*, Molecular characterization of three novel perforins in common carp (Cyprinus carpio L.) and their expression patterns during larvae ontogeny and in response to immune challenges, BMC Veterinary Research, 2018, 14: 299.

6.Hua Li#, Ting Li#, Yujie Guo, Yujun Li, Yan Zhang, Na Teng, Fumiao Zhang* and Guiwen Yang*, Molecular characterization and expression patterns of a non-mammalian toll-like receptor gene (TLR21) in larvae ontogeny of common carp (Cyprinus carpio L.) and upon immune stimulation, BMC Veterinary Research, 2018, 14:153.

7.Shijuan Shan#, Dezhi Liu#, Rongrong Liu, Yaoyao Zhu, Ting Li, Fumiao Zhang, Liguo An, Guiwen Yang*, Hua Li*, Non-mammalian Toll-like receptor 18 (Tlr18) recognizes bacterial pathogens in common carp (Cyprinus carpio L.):Indications for a role of participation in the NF-κB signaling pathway, Fish& Shellfish Immunology, 2018.1, 72: 187-198.

8.Cong Xu#, Hua Li#, Miao Yin, Tao Yang, Liguo An* and Guiwen Yang*, Osteopontin is involved in TLR4 pathway contributing to ovarian cancer cell proliferation and metastasis, Oncotarget, 2017, 8(58): 98394-98404.

9.Hua Li#, Guiwen Yang#, Fei Ma, Ting Li, Huiting Yang, JH Rombout, Liguo An*, Molecular characterization of a fish-specific toll-like receptor 22 (TLR22) gene from common carp (Cyprinus carpio L.): Evolutionary relationship and induced expression upon immune stimulants. Fish& Shellfish Immunology, 2017, 63: 74-86.

10.Ting Li#, Hua Li#, Shaoqing Peng, Fumiao Zhang, Liguo An*, Guiwen Yang*. Molecular characterization and expression pattern of X box-binding protein-1 (XBP1) in common carp (Cyprinus carpio L.): Indications for a role of XBP1 in antibacterial and antiviral immunity. Fish& Shellfish Immunology, 2017, 67: 667-674.

11.Ailing Lu#, Hua Li#, Junling Niu, Shuxian Wu, Guang Xue, Xiaomin Yao, Qiuhong Guo, Nianhong Wan, Paride Abliz, Guiwen Yang, Liguo An*, Guangxun Meng*, Hyperactivation of the NLRP3 Inflammasome in Myeloid Cells Leads to Severe Organ Damage in Experimental Lupus, The Journal of Immunology, 2017, 198 (3): 1119-1129.

12.Hua Li#, Hongyan Guo#, Shijuan Shan, Chenchen Qi, Liguo An, Guiwen Yang. Characterization and expression pattern of a novel β-defensin in common carp (Cyprinus carpio L.): implication for the role in mucosal immunity. Bioscience, Biotechnology, and Biochemistry, 2014, 78 (3): 430-437.

13.Liming Mao#, Liping Zhang#, Hua Li#, Wei Chen，Hongbin Wang，Shuxian Wu，Caiqin Guo，Ailing Lu，Guiwen Yang，Liguo An，Paride Abliz and Guangxun Meng. Pathogenic Fungus Microsporum canis Activates the NLRP3 Inflammasome. Infection and Immunity, 2014, 82 (2): 882-892.

14.Hua Li#, Fumiao Zhang#, Hongyan Guo, Yaoyao Zhu, Jinduo Yuan, Guiwen Yang, Liguo An. Molecular Characterization of Hepcidin Gene in Common Carp (Cyprinus carpio L.) and Its Expression Pattern Responding to Bacterial Challenge. Fish & Shellfish Immunology, 2013, 35 (3): 1030-1038.

15.Hua Li#, Shuxian Wu#, Liming Mao#, Guowei Lei, Liping Zhang, Ailing Lu, Liguo An, Guiwen Yang, Paride Abliz, Guangxun Meng. Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome. Protein & Cell, 2013, 4 (7): 529-538.

16.Guowei Lei#, Mingkuan Chen#, Hua Li#, Jun-Ling Niu, Shuxian Wu, Liming Mao, Ailing Lu, Hongbin Wang, Wei Chen, Bin Xu, Qibin Leng, Cunshuan Xu, Guiwen Yang, Liguo An, Li-Ping Zhu, Guangxun Meng. Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome. Cell research, 2013, 23 (7): 965-968.

17.Yongfen Xu#, Hua Li#, Wei Chen#, Xiaomin Yao, Yue Xing, Xun Wang, Jin Zhong, Guangxun Meng. Mycoplasma hyorhinis Activates the NLRP3 Inflammasome and Promotes Migration and Invasion of Gastric Cancer Cells. PLoS ONE, 2013, 8(11): e77955.

五、获奖

1.2019年山东省高等学校科学技术奖，三等奖（3/8）。

2.2018年山东省省级教学成果奖，二等奖（9/9）。