一、个人简介

张鸿雁，教授，博士生导师，省食品学会常务理事，山师东岳学者。2007年于天津科技大学获博士学位，2003年于齐鲁工业大学获得硕士学位。2017年获国家留学基金委资助赴加拿大英属哥伦比亚大学访学。主持国家自然科学基金2项，国家重点研发计划子课题、国家博士后基金、山东省自然科学基金重点及面上项目各1项。以第一或通讯作者发表SCI论文31篇，其中一区10篇，二区12篇；授权发明专利6项；主编教材1部，参编4部；获省食品学会科技进步一等奖，指导2人次获省优秀硕士学位论文，指导1人次获省研究生优秀成果三等奖，获第十二届“挑战杯”创业计划竞赛省金奖，获第十三届“挑战杯”课外学术科技作品竞赛省一等奖。主讲《食品化学》、《食品安全风险分析》、《食品安全管理与控制》、《食品安全学》。

二、研究方向

1、食品安全快速检测方法研究：主要针对食品中的农兽药残留、雌激素干扰物类危害物等建立试纸条快速检测方法、光热传感器快速检测方法及便携式检测仪器研发等。

2、潜在新型食品安全危害物的筛查及鉴定：主要建立雌激素干扰物的非定向筛查方法，并将其用于食品加工过程中产生的潜在新型雌激素干扰物的筛查鉴定；建立纳米塑料的定性定量检测方法。

3、循环肿瘤细胞的检测方法研究：建立循环肿瘤细胞检测方法，并将其用于食品功能因子、饮食模式等饮食因素对癌症转移的影响机理研究；循环肿瘤细胞在体捕获方法用于癌症早期诊断的研究等。

三、承担项目

1、山东省自然基金重点项目，ZR202010290039，肉制品加工链危害物快速检测技术体系的建立，2021/01-2023/12，30万元，在研，主持。

2、国家自然基金面上项目，31871874，乳制品加工中产生的潜在新型雌激素干扰物的非定向筛查与鉴定，2019/01-2022/12，60万元，在研，主持。

3、国家重点研发计划子课题，2016YFD0401101，跨境食品潜在、新发有害物及其代谢物多元识别技术研究与数据库构建子课题，2016/07-2020/12，98.28万元，在研，主持。

4、山东省自然科学基金面上项目，ZR2016CM47，基于免疫磁珠及石墨烯光热效应的沙门氏菌快速、灵敏检测方法研究，2017/01-2019/02，13万元，已结题，主持。

5、国家自然科学基金青年项目，21105058，环境雌激素对单细胞内雌激素受体作用的原位、动态、定量研究，2012/01-2014/12，25万元，已结题，主持。

6、国家博士后科学基金项目，20100471569，己烯雌酚对单细胞内雌激素受体作用的原位、动态、定量研究，2011/01-2014/10，3万元，已结题，主持。

四、教学科研成果

发表论文：

[1] Du SY, Lu Z, Gao LX, Ge YY, Xu XY,Zhang HY*, Salmonella typhimurium detector based on the intrinsic peroxidase-like activity and photothermal effect of MoS2. Microchimica Acta, November 2020, 187:627.

[2] Li XQ, Liu XF, Jia ZZ, Wang, T,Zhang HY*, Screening of estrogenic endocrine-disrupting chemicals in meat products based on the detection of vitellogenin by enzyme-linked immunosorbent assay. Chemosphere, January 2021, 263:128251.

[3] Lu LX, Ge YY, Wang X, Lu Z, Wang T,Zhang HY*, Du SY*, Rapid and sensitive multimode detection of Salmonella typhimurium based on the photothermal effect and peroxidase-like activity of MoS2@Au nanocomposite. Sensors and Actuators: B. Chemical, August 2021, 326:128807.

[4] Wang ML, Wang Q, Li XQ, Lu LX, Du SY,Zhang HY*, Selection and Identification of Diethylstilbestrol-Specific Aptamers Based on Magnetic-bead SELEX. Microchemical Journal, July 2020, 159:105354.

[5] Zhang JH, Zang LG, Wang T, Wang XW, Jia M, Zhang D andZhang HY*, A solid-phase extraction method for estrogenic disrupting compounds based on the estrogen response element. Food Chemistry, July 2020, 333:127529.

[6] Wang Y, Su SP, Du SY, Gao Y, Xu ZX andZhang HY*, Rapid detection for Salmonella typhimurium by conventional resistive temperature sensor based on photothermal effect of carboxylated graphene oxide. Food Analytical Methods, September 2020, 13:1755-1763.

[7] Jia M, Pang SX, Liu XY, Mao YF, Wu CC andZhang HY*, Effect of dietary phytochemicals on the progression of breast cancer metastasis based on the in vivo detection of circulating tumor cells. Journal of Functional Foods, December 2019, 65: 103752.

[8] Du X, Zhang ZH, Zheng XD,Zhang HY, Dong D, Zhang ZG, Liu M, Zhou J*, An electrochemical biosensor for the detection of epithelial-mesenchymal transition. Nature Communication, 2020, 11(1):192. (1区)

[9] Liu MY, Zhang SQ, Du SY, Pang SX, Liu XY andZhang HY*, A high throughput screening method of endocrine disrupting chemicals in tap water and milk samples based on estrogen receptor α and gold nanoparticles. Analytical Methods, November 2019, 12: 200-204.

[10] Lu LX, Wang ML, Zhang D andZhang HY*, Establishment of an immunofiltration strip for the detection of 17β-estradiol based on the photothermal effect of black phosphorescence. Analyst, 2019, 144:6647-6652.

[11] Du SY, Wang Y, Liu ZC, Xu ZX* andZhang HY*, A portable immune-thermometer assay based on the photothermal effect of graphene oxides for the rapid detection of Salmonella typhimurium. Biosensors and Bioelectronics, 2019, 144:111670.

[12] Jia M, Mao YF, Wu CC, Wang S* andZhang HY*, A platform for primary tumor origin identification of circulating tumor cells via antibody cocktail-based in vivo capture and specific aptamer-based multicolor fluorescence imaging strategy. Analytica Chimica Acta, 2019, 1082: 136-145.

[13] Jia M, Liu ZC, Wu CC, Zhang Z, Ma LY, Mao YF, Lu XN andZhang HY*, Detection of Escherichia coli O157:H7 and Salmonella enterica serotype Typhimurium based on cell elongation induced by beta-lactam antibiotics. Analyst, 2019, 144: 4505-4512.

[14] Jia M, Liu JJ, Zhang JH andZhang HY*, An immunofiltration strip method based on the photothermal effect of gold nanoparticles for the detection of Escherichia coli O157:H7. Analyst, 2019, 144: 573-578.

[15] Zhang D, Du SY, Su SP, Wang Y,Zhang HY *, Rapid detection method and portable device based on the photothermal effect of gold nanoparticles, Biosensors and Bioelectronics, 2019, 123:19-24.

[16] Jia M, Li SM, Zang LG, Lu XN,Zhang HY*, Analysis of biomolecules based on the surface enhanced raman spectroscopy. Nanomaterials, 2018, 8(9): 730-757.

[17] Zhang Z, Wang Q, Han LY, Du SY, Yu HF,Zhang HY*, Rapid and sensitive detection of Salmonella typhimurium based on the photothermal effect of magnetic nanomaterials. Sensors and Actuators B: Chemical, 2018, 268: 188-194.

[18] Wu CC, Liu ZC, Zhang Z, Jiang YH,Zhang HY*, The effect of selected food phytochemicals on breast cancer metastasis based on in vivo capture of circulating tumor cells, Food & Function, 2017, 8: 2698-2701.

[19] Xiao L, Zhang Z, Wu CC, Han LY,Zhang HY*. Molecularly imprinted polymer grafted paper-based method for the detection of 17β-estradiol. Food Chemistry, 2017, 221: 82-86.

[20]Zhang HY, Zhang Z, Wang YH, Wu CC, Li QL, Tang B. Rapid and sensitive detection of cancer cells based on the photothermal effect of graphene functionalized magnetic microbeads, ACS Applied Materials & Interfaces, 2016, 10: 29933-29938.

[21] Zhou JH, Zheng YP, Liu JJ, Bing X, Hua JJ,Zhang HY*, A paper-based detection method of cancer cells using the photo-thermal effect of nanocomposite, Journal of Pharmaceutical and Biomedical Analysis, 2016, 117: 333-337.

[22]Zhang HY, Jia ZZ, Wu CC, Zang LG, Yang GW, Chen ZZ, Tang B, In vivo capture of circulating tumor cells based on transfusion with a vein indwelling needle, ACS Applied Materials & Interfaces, 2015, 7: 20477-20484.

[23]Zhang HY, Wang YH, Li QL, Zhang FM, Tang B, A size amplified immune magnetic microbeads strategy in the rapid detection of circulating tumor cells, Chemical Communications, 2014, 50: 7024-7027.

[24]Zhang HY, Wang MM, Wang Y, Li QL, Zhou JH, Huo F, Tang B, Preparation and application of an immunoaffinity column based on an antibody with strong affinity and packing material with good stability, Food Additives & Contaminants: Part A, 2013, 30(5): 853-860.

[25] Zhu D,Zhang HY*, Bing X, Preparation of an immunoaffinity column for the clean-up of fermented food samples contaminated with citrinin, Food Additives & Contaminants: Part A, 2013, 30: 389-394.

[26]Zhang HY, Yuwei Wei, Jianhua Zhou, Jinxin He*, Preparation and Application of a Molecular Imprinting Matrix Solid Phase Dispersion Extraction for the Determination of Olaquindox in Chicken by High Performance Liquid Chromatography, Food Analytical Methods, 2012, 6(3).

[27]Zhang HY, Fang GZ, Wang S. Applications and recent developments of multi-analyte simultaneous analysis by enzyme-linked immunosorbent assays, Journal of Immunological Methods, 2011, 368: 1-23.

[28]Zhang HY, Wang S, Review on enzyme-linked immunosorbent assays for sulfonamide residues in edible animal products, Journal of Immunological Methods, 2009, 350: 1-13.

[29]Zhang HY, Zhang Y, Wang S, Zang LG, Validation and comparative studies of four sulfonamide immunoassays based on the same generic polyclonal antibody, Applied Biochemistry and Biotechnology, 2009, 158(3): 642-652.

[30]Zhang HY，Zhang Y, Wang S, Development of flow-through and dip-stick immunoassays for screening of sulfonamide residues, Journal of Immunological Methods, 2008, 337: 1-6.

[31]Zhang HY, Wang L, Zhang Y, Fang GZ, Zheng WJ, Wang S, Development of an enzyme-linked immunosorbent assay for seven sulfonamide residues and investigation of matrix effects from different food samples, Journal of Agricultural and Food Chemistry, 2007, 55: 2079-2084.

[32]Zhang HY, Duan ZJ, Wang L, Zhang Y, Wang S, Hapten synthesis and development of polyclonal antibody-based multi-sulfonamide immunoassays, Journal of Agricultural and Food Chemistry, 2006, 54: 4499-4505.

[33] Wang S,Zhang HY, Wang L, Duan ZJ, Kennedy I, Analysis of sulfonamide residues in edible animal products, Food Additives & Contaminants: Part A, 2006, 23(4): 362-384.

授权发明专利：

[1]张鸿雁，杜淑媛，刘兆臣，苏树朋，王莹。一种集检测载体与信号产生于一体的温度计快速检测方法，中国发明专利，专利号ZL 2018 1 0725536.8。

[2]张鸿雁，刘兆臣，杜淑媛。一种基于细菌增长对细菌快速镜检的方法，中国发明专利，专利号ZL 2017 1 0757047.6。

[3]张鸿雁，张震，罗钰。一种基于免疫磁性纳米材料光热效应的鼠伤寒沙门氏菌快速检测方法，中国发明专利，专利号ZL 2017 1 0756436.7。

[4]张鸿雁，肖蕾，刘兆臣，张震。用于检测17ß-雌二醇的分子印迹聚合物试纸条及其制备方法，中国发明专利，专利号ZL 2016 1 0805554.8。

[5]张鸿雁，郑艳苹，刘静静，周建华。一种基于纳米材料光热效应的细胞检测方法及其装置，中国发明专利，专利号ZL 2015 1 0045324.1。

[6]张鸿雁，王言红，唐波.用于外周血中循环肿瘤细胞捕获的免疫磁性微球,中国发明专利，专利号ZL 2014 1 0153844.X。

主编或参编书籍：

[1]《食品安全风险分析理论与应用》，张鸿雁主编，2019年，科学出版社；

[2]《Food Chemical Hazard Detection, Development and application of new technologies》, “Recent developments in liquid chromatography-mass spectrometry for the detection of food chemical hazards”, Shuo Wang, 2014, WILEY Blackwell.

[3]《酶联免疫吸附分析方法(基本原理及其在食品化学污染物检测中的应用)》，王硕主编，2010年，科学出版社；

[4]《食品安全学》，王硕主编，2016年，科学出版社；

[5]《食品安全检测技术》，王硕主编，2016年，化学工业出版社。

五、获奖情况

获2020年第十二届“挑战杯”山东省大学生创业计划竞赛优秀指导教师称号。

以第一完成人获2020年度山东省高等学校科学技术奖二等奖。

以第一完成人获2020年食品科学技术学会科学技术奖——技术进步奖一等奖。

2019年获555000Jc线路检测中心第四届优秀研究生指导教师。

2010年获天津市优秀博士论文。