刘树真

日期: 2021/01/30 作者: 浏览量:


一、个人简介

刘树真,教授,博士生导师。2005年由中国科学院动物研究所(北京)博士毕业,作为引进人才到555000Jc线路检测中心任教。任中国动物学会细胞与分子显微技术分会常务理事,山东动物学会常务理事。

至今教授了遗传学、分子生物学、组织胚胎学、发育生物学、普通动物学、动物胚胎工程、生殖生理学、人文生物学等多门本科、研究生及博士生课程。已毕业研究生22名,在校硕士生数5人,在校博士生数1人。毕业研究生的就业方向:大中城市医院的不孕不育生殖中心;继续攻读博士学位;初高中的生物教师;生物公司的科研人员。

自2015起在QQ(QQ号:921845552)空间的撰写心理学和教育学方面的日志,并转发了大量的相关文章,对学生进行心理学和教育学等知识的普及。

二、研究方向

科研方面:主要从事环境毒物对哺乳动物亲代及子代卵母细胞减数分裂、受精以及胚胎发育等方面的科学研究,希望能深入研究人类的“不孕不育症”的致病机理并探寻治疗方法。

教学方面:人文理念(思想)或社会行为所依赖的生物学基础。

三、承担项目

作为项目主持人主持国家自然科学基金2项,省部级课题1项,省级课题3项,参与国家级课题2项,省级课题2项。指导大学生创新创业项目国家级2项,省级1项校级2项。

1、国家自然科学基金面上基金项目,31571549、 多氯联苯对小鼠生殖细胞印迹基因DNA甲基化的影响及其跨代传递、2016/01-2019/12、90万、在研、主持。

2、国家自然科学基金青年基金项目,31101068、多氯联苯同系物Aroclor-1254对小鼠卵母细胞减数分裂的影响及分子的机理研究、2012/1-2014/12、22万元、结题、主持。

3、山东省科技厅资助的山东省优秀中青年科学家科研奖励基金项目,2007BS02014、提高小鼠球形精子授精胚胎构建效率的研究、2007/12-2010/12、6万元、结题、主持。

4、山东省教育厅基础研究项目,J07YG02、利用球形精子制备转基因小鼠的究、2007/12-2010/12,5万元、结题、主持。

5、国家自然科学基金,31172040、肝受体类似物(Liver Receptor Homolog 1,LRH 1)在雌鼠生殖过程中的作用及其机制、2012/1-2015/12、59万元、在研、参加。

6、山东省科技厅资助的山东省优秀中青年科学家科研奖励基金项目,2008BS02016、Pyk2在小鼠卵子受精过程中的功能研究、2008/12-2010/12、6万元、结题、参加。

四、教学科研成果(论文、专著、专利等)

论文发表情况:

1. Jian-Mei Zhang*, Qiu-Yue Wang*, Xiao-Ying Han, Qi-Long He, Li Liu, Yong-Tao Zhang, Xiao-Qian Meng, Dong Cheng, Tian-Liang Zhang and Shu-Zhen Liu*.Effects of 2,3',4,4',5-pentachlorobiphenyl exposure during pregnancy on DNA methylation in the testis of offspring in the mouse. Reproduction, Fertility and Development, 2020,32(12) 1048-1059.(SCI收录:IF=1.718)

2. Qi-Long He*, Tian-Qi Lyu*, Yong-Tao Zhang, Hai-Quan Wang, Qian Zhou, Jian-Mei Zhang, Yuan-Yuan Liu, Jia-Shuo Li, Li-Gang Jiang, Dong Cheng, Zhao-Jia Ge, Shu-Zhen Liu*. Effects of intrauterine exposure to 2,3',4,4',5-pentachlorobiphenyl on the reproductive system and sperm epigenetic imprinting of male offspring. Journal of Applied Toxicology. 2020 May 17. doi: 10.1002/jat.3992.(SCI收录:IF=2.997)

3. Qi‑Long He, Xu‑Yu Wei, Xiao‑Ying Han, Qian Zhou, Hai‑Quan Wang, Nai‑Zheng Ding, Xiao‑Qian Meng, Heide Schatten, Qing‑Yuan Sun*, Shu‑Zhen Liu*. Effects of 2,3',4,4'5 - pentachlorobiphenyl exposure during pregnancy on epigenetic imprinting and maturation of offspring's oocytes in mice. Archives of Toxicology.2019, 93:2575–2592.(SCI收录:IF=5.741)

4. Tao Zhong, Jianmei Zhang, Xiaoying Han, Xiaoxiao Gongye, Tianqi Lyu, Menghan Jiang, Kaiwei Yu, Xiaoqian Meng, Dong Cheng, Hui Lyu, Tianliang Zhang, Lei Zhang, Shuzhen Liu*. 3,3',4,4',5- Pentachlorobiphenyl influences mitochondrial apoptosis pathway in granulosa cells. Journal of Cellular Biochemistry. 2019,Sep;120(9):15337-15346. doi: 10.1002/jcb.28801.(SCI收录:IF=3.448)

5. Liu SZ*, Yu CN, Cheng D, Han XY, Jiang LG, Zheng RB, Meng XQ, Zhang TL, Huo LJ. Aroclor 1254 impairs the development of ovarian follicles by inducing the apoptosis of granulosa cells. Toxicology Research, 2015,4,302-310.(DOI: 10.1039/c4tx00104d)。(SCI收录:IF=3.273)

6. Liu SZ*, Jiang LG, Meng XQ, Han XY, Cheng D,Zhang TL, Miao YL. Effects of Aroclor 1254 on In Vivo Oocyte Maturation in the Mouse. PloS one.2014, 9(7):e102064.(SCI收录:IF=3.534)

7. Liu SZ*,Wei ZF, Meng XQ, Han XY, Cheng D, Zhong T, Zhang TL, Wang ZB. Exposure to Aroclor-1254 impairs spindle assembly during mouse oocyte maturation. Environ Toxicol. 2015 Jul 15. doi: 10.1002/tox.22169. [Epub ahead of print](SCI收录:IF=3.197)

8. Liu SZ*, Jiang L, Zhong T, Kong S, Zheng R, Kong F, Zhang C, Zhang L, An L*. Effect of Acrylamide on Oocyte Nuclear Maturation and Cumulus Cells Apoptosis in Mouse In Vitro. PLoS One. 2015 Aug 14;10(8):e0135818. doi: 10.1371/journal.pone.0135818. eCollection 2015.(SCI收录:IF=3.534)

9. Guo C, Meng XQ, Bai J, Chen C, Liu T, Liu SZ, Zhang C, Li WP. Expression and localization of transcription factors SNAIL and SLUG in mouse ovaries and pre-implantation embryos. Cell Tissue Res, 2014, 358(2):585-95.(SCI收录:IF=3.333)

10. Zhang F, Huang YH, Liu SZ, Zhang L, Zhang XX*. Pseudomonas reactans, a Bacterial Strain Isolated from the Intestinal Flora of Blattella Germanica with Anti-Beauveria bassiana Activity. Environmental Entomology, 2013, 42(3):453-459.(SCI收录:IF=1.424)

11.刘愿,孟晓倩,刘树真(通讯作者)。小鼠无透明带胚胎培养方法的优化。555000Jc线路检测中心学报(自然科学版),2011, 26(2):106-107.

12.刘愿,孟小倩,李秋艳,潘维锋,刘树真(通讯作者)。小鼠无透明带核移植技术。生命的化学,2010, 30(6):949-952(核心期刊)。

13.刘建伟,孟晓倩,陈玉洁,潘杰,艾洪宾,刘树真(通讯作者)。五种染色方法对小鼠圆形精子染色效果的比较。生物医学工程研究,2010, 29(2):113~116.

14. Jiang Y, Chen T, Wang K, Jiang MX, Liu SZ, Ouyang YC, Sun QY, Chen DY. Different fates of donor mitochondrial DNA in bovine-rabbit and cloned bovine-rabbit reconstructed embryos during preimplantation development. Front Biosci. 2006,11:1425-32.(SCI收录:IF=4.249)

15. Yan LY, Shi LH, Sheng HZ, Liu SZ, Huang JC, Zhu ZY, OuYang YC, Lei ZL, Song XF, Sun QY, Chen DY. Dynamic changes in NuMA and microtubules in monkey-rabbit nuclear transfer embryos. Front Biosci. 2006,11:1892-900.(SCI收录:IF=4.249)

16. Zhang YL, Chen T, Jiang Y, Zhong ZS, Liu SZ, Hou Y, Schatten H, Chen DY, Sun QY. Active demethylation of individual genes in intracytoplasmic sperm injection rabbit embryos. Mol Reprod Dev. 2005,72(4):530-3.(SCI收录:IF=2.675)

17. Liu SZ, Jiang MX, Yan LY, Jiang Y, Zhang YL, Ouyang YC, Sun QY, Chen DY. Parthenogenetic and nuclear transfer rabbit embryo development and apoptosis after activation treatments. Mol Reprod Dev. 2005,72(1):48-53.(SCI收录:IF=2.675)

18. Liu SZ, Yao LJ, Jiang MX, Lei ZL, Zhang LS, Zhang YL, Zheng YL, Sun QY, Chen DY. Apoptosis in rabbit embryos produced and by fertilization and nuclear transfer with fibroblasts and cumulus cells. Reproduction. 2005,130(3):359-66.(SCI收录:IF=3.262)

19. Jiang MX, Zheng YL, Liu SZ, Yang CX, Zhang LS, Ouyang YC, Sun QY and Chen DY. Effects of oocyte collection time and injection position on pronucleus formation and blastocyst development in round spermatid injection mouse. Zygote 2005,13(3):249-53(SCI收录:IF=1.323)

20. Chen T, Zhang YL, Jiang Y, Liu SZ, Schatten H, Chen DY, Sun QY. The DNA methylation events in normal and cloned rabbit embryos. FEBS Lett. 2004,578(1-2):69-72.(SCI收录:IF=3.341)

21. Liu SZ,Zhou ZM, Chen T, Zhang YL, Wen DC, Kou ZH, Li ZD, Sun QY, Chen DY. Blastocysts produced by nuclear transfer between chicken blastodermal cells and rabbit oocytes. Mol Reprod Dev. 2004, 69(3):296-302.(SCI收录:IF= 2.675)

22. Jiang MX, Yang CX, Zhang LS, Zheng YL, Liu SZ, Sun QY, Chen DY. The effects of chemical enucleation combined with whole cell intracytoplasmic injection on panda-rabbit interspecies nuclear transfer. Zygote. 2004,12(4):315-20(SCI收录:IF=1.323)

23. Jiang Y, Liu SZ, Zhang YL, Jiang MX, Sun QY, Chen DY. The fate of mitochondria in Ibex-hirus reconstructed early embryos. Acta Biochim Biophys Sin. 2004,36(5):371-4.(SCI收录:IF=2.089)

24. Zhang LS, Zhang KY, Yao LJ, Liu SZ, Yang CX, Zhong ZS, Zheng YL, Sun QY, Chen DY. Somatic nucleus remodelling in immature and mature Rassir oocyte cytoplasm. Zygote. 2004,12(2):179-84.(SCI收录:IF=1.323)

五、获奖

在生命科学院首届青年教师教学能手大赛中获二等奖,多次荣获本科生及研究生校级优秀教学奖。2010年获“555000Jc线路检测中心青年教学能手”荣誉称号。