一、 简介

副教授，硕士生导师

邮箱：tianxiaoyu@sdnu.edu.cn

       研究方向：

主要从事细胞骨架、细胞自噬、细胞膜与细胞器等相关结构的功能与分子机制研究。特别关注微管相关结构纤毛的形态结构与功能，包括蛋白修饰、蛋白分子互作等过程对纤毛组装和解聚的调控机制，纤毛在生理和病理中的功能和作用机制等。关注由纤毛损伤导致的疾病及其分子机制的基础研究。同时关注相关信号通路在细胞中的传递与调控方式，采用细胞、生化和分子手段解析相关通路的分子构成、信号传递方式和生理意义。

二、 承担项目

1、国家自然科学基金青年基金，2021.1-2023.12，主持。

2、山东省自然科学基金青年基金，2021.1-2023.12，主持。

3、中国博士后基金面上项目，2020.7，主持。

三、 教学科研成果（论文、专著、专利等）

1. Xiaoyu Tian*, Kaiyue Zhang*, Renjie Hong*, Hanyu Wang, Xifeng Dong, Jun Zhou, Yunfan Yang#, and Min Liu#. Primary cilia restrict autoinflammation by mediating PD-L1 expression, Science Bulletin, 2024.

2. Xiaoyu Tian*#, Huijie Zhao*, and Jun Zhou#. Organization, functions, and mechanisms of the BBSome in development, ciliopathies, and beyond. eLife, 2023, e87623. （#共同通讯作者）

3. Xiaoyu Tian, Ziyong Cui, Song Liu, Jun Zhou#, and Rutao Cui#. Melanosome transport and regulation in development and disease, Pharmacology & Therapeutics, 2021, 219: 107707.

4. Xiaoyu Tian, Junlin Teng#, and Jianguo Chen#. New insights regarding SNARE proteins in autophagosome-lysosome fusion, Autophagy, 2021, 17(10): 2680-2688.

5. Xiaoyu Tian, Pengli Zheng, Chenqian Zhou, Xurui Wang, Hua Ma, Wei Ma, Xiaokai Zhou, Junlin Teng#, and Jianguo Chen#. DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B, Autophagy, 2020, 16(5): 797-810.

6. Renjie Hong*; Yanjie Tan*; Xiaoyu Tian*; Zhenzhou Huang; Jiaying Wang; Hua Ni; Jia Yang; Weiwen Bu; Song Yang; Te Li; Fan Yu; Weilong Zhong; Tao Sun; Xiaohong Wang; Dengwen Li; Min Liu; Yunfan Yang#; Jun Zhou#; XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis, EMBO reports, 2024, 25(3): 1055-1074. （*共同第一作者）

7. Pengli Zheng*, Qingzhou Chen*, Xiaoyu Tian*, Nannan Qian, Peiyuan Chai, Bing Liu, Junjie Hu, Craig Blackstone, Desheng Zhu, Junlin Teng#, and Jianguo Chen#. DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling, Cell Research, 2018, 28(8): 833-854. （*共同第一作者）

8. Renjie Hong, Xiaoyu Tian, Hongbo Ma, Hua Ni, Jia Yang, Weiwen Bu, Te Li, Song Yang, Dengwen Li, Min Liu, and Yanjie Tan. Primary cilium-mediated signaling cascade suppresses age-related biliary fibrosis. 2023, Journal of Cellular Physiology, 2023, 238(11): 2600-2611.

9. Shuaiya Ma, Ye Tian, Jiali Peng, Chaojia Chen, Xueqi Peng, Fabao Zhao, Zhenyu Li, Mengzhen Li, Fangcheng Zhao, Xue Sheng, Runzhe Zong, Yiquan Li, Jiwei Zhang, Mingyan Yu, Qingfen Zhu, Xiaoyu Tian, Yuyang Li, Markus R Neckenig, Huiqing Liu, Peng Zhan, Xuetian Yue, Zhuanchang Wu, Lifen Gao, Xiaohong Liang, Xinyong Liu, Chunyang Li, and Chunhong Ma. Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models. Science Translational Medicine, 2023, 15(722), eadg6752.