李国荣 教授 博士 博士生导师

教育经历：

1981-1985  555000Jc线路检测中心生物系，本科生

1985-1988  555000Jc线路检测中心生物系，动物学 硕士研究生

1997-2000  中国科学院海洋研究所，海洋生物 博士研究生

工作经历：

1987-2001 555000Jc线路检测中心 生物系，助教、讲师、副教授

2001-2003 Post-doctoral Research Associate, Kumamoto University, Japan

2003-2004 555000Jc线路检测中心 555000Jc线路检测中心，教授

2004-2009 Visiting Fellow, National Cancer Institute, National Institutes of Health, USA

2009-2013 555000Jc线路检测中心 555000Jc线路检测中心，教授、博士生导师

2013-2014 Visiting Fellow, Warwick University, UK

2014-至今 555000Jc线路检测中心 555000Jc线路检测中心，教授、博士生导师

研究兴趣、领域：

1、抗癌药物抑制癌细胞增殖和迁移的信号转导通路研究

2、抗衰老药物对硬骨鱼延缓衰老延长寿命的作用机理研究

代表性论文：

1. Liu S, Zheng Z, Ji S; Liu T, Hou Y, Li S, Li GR., Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri. Fish and Shellfish Immunology.80:473-479, 2018.

2. Ji S,, Zheng Z, Liu S, Ren G, Gao J, Zhang Y, Li GR. Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. Exp Cell Res. 370(2):292-302, 2018.

3. Zheng Z, Zhu W, Yang B, Chai R, Liu T, Li F, Ren G, Ji S, Liu S, Li GR*. The co-treatment of metformin with flavone synergistically induces apoptosis through inhibition of PI3K/AKT pathway in breast cancer cells. Oncology Letters 15: 5952-5958, 2018

4. Liu T, Liu S, Ma L, Li F, Zheng Z, Chai R, Hou Y, Xie Y, Li GR* Oogenesis, vitellogenin-mediated ovarian degeneration and immune response in the annual fish Nothobranchius guentheri. Fish & Shellfish Immunology 66: 86-92. 2017

5. Liu T, Ma L, Zheng Z, Li F, Liu S, Xie Y, Li GR*. Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fsh Nothobranchius guentheri. Oncotarget 8(33):55422-55434. 2017.

6. Chai R, Fu H, Zheng Z, Liu T, Ji S, Li GR*. Resveratrol inhibits proliferation and migration through SIRT1 mediated post translational modifcation of PI3K/AKT signaling in hepatocellular carcinoma cells. Mol. Med. Rep. 16(6): 8037-8044, 2017.

7. Yang B, Zhu W, Zheng Z, Chai R, Ji S, Ren G, Liu T, Liu Z, Song T, Li F, Liu S, Li GR^* Fluctuation of ROS regulates proliferation and mediates inhibition of migration by reducing the interaction between DLC1 and CAV-1 in breast cancer cells. In Vitro Cell Dev Biol Anim. 53(4):354-362. 2017

8. Zhu W, Ma L, Yang B, Zheng Z, Chai R, Liu T, Liu Z, Song T, Li F, Li GR* Flavone inhibits migration through DLC1/RhoA pathway by decreasing ROS generation in breast cancer cells. In Vitro Cell Dev Biol Anim.  52(5):589-97. 2016

9. Liu T, Qi H, Ma L, Liu Z, Fu H, Zhu W, Song T, Yang B, Li GR*. Resveratrol attenuates oxidative stress and extends lifespan in the annual fish Nothobranchius Guentheri. Rejuvenation Res. 18(3):225-33. 2015

10. Zhu W, Yang B, Fu H, Ma L, Liu T, Chai R, Zheng Z, Zhang Q, Li GR *. Flavone inhibits nitric oxide synthase (NOS) activity, nitric oxide production and protein S-nitrosylation in breast cancer cells. Biochemical and Biophysical Research Communications (BBRC). 458:590-595. 2015

11. Ma L, Zhu W, Liu T, Fu H, Liu Z, Yang B, Song T, Li GR*, H₂O₂ Inhibits Proliferation and Mediates Suppression of Migration via DLC1/RhoA Signaling in Cancer Cells. Asian Pac J Cancer Prev. 16(4):1637-42. 2015.

12. Yu X, Li GR*. Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fishNothobranchiusguentheri. Exp Gerontol. 47:940-949. 2012.

14.  Li GR, Du XL, Vass W, Papageorge A, Lowy DR* Qian X*. Full activity of the deleted in liver cancer1(DLC1)tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase(FAK). Proc Natl Acad Sci U S A (PNAS). 108(41):17129-17134. 2011.

15. Qian X, Li GR, Vass WC, Papageorge AG, Walker R, Asnaghi L, Steinbach PJ, Tosato G, Hunter K, Lowy DR*. The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis. CANCER CELL; 16(3):246-58. 2009.

16. Qian X^#,  Li GR^#, Asmussen HK, Asnaghi L, Vass WC, Braverman R, Yamada KM, Popescu NC, Papageorge AG, Lowy DR. Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Proc Natl Acad Sci U S A. 104(21):9012-7. 2007

主持的研究课题:

1．国家自然科学基金：白藜芦醇通过SIRT1抑制假鳃自发肝脏肿瘤的作用及其表 观遗传调控机制 (31672377)

2．国家自然科学基金：白藜芦醇通过SIRT1 抑制肿瘤发生延缓贡氏假鳃鳉衰老的机理研究（31340035）

荣誉、奖励及参加学术团体的情况：

2015年获555000Jc线路检测中心优秀教学奖

2009年获NIH FARE (Fellows Awards for Research Excellence) Winner.

2001年获山东省优秀博士论文奖

2014年 山东细胞生物学会理事

2014年 山东动物学会理事

联系方式：

济南市文化东路88号 555000Jc线路检测中心 555000Jc线路检测中心（250014）

电话：0531-86182690

邮箱：grli@sdnu.edu.cn