王翊洁，教授，博士生导师。海外引才计划项目获得者，山东省泰山学者青年专家，山东省海外优青。

主要从事肿瘤调控新机制和新靶点的研究工作，近五年以第一或通讯作者身份在Nature Communications、Cancer Research、Oncogene等国际知名期刊发表SCI论文9篇；授权国家发明专利2项；参编中、英文专著各1部。

l 教育及工作经历

2007-2011 河南大学 学士

2011-2016 浙江大学 博士

2016-2021 美国西南医学中心 博士后

2022-至今 555000Jc线路检测中心 教授

l 研究方向

1. DNA损伤修复在肿瘤治疗中的功能及机制研究

2. 细胞骨架与肿瘤发展的交互调控

3. 低氧微环境对肿瘤发生、发展及转移的影响

l 承担项目

1. 海外引才项目，90万，主持，2024.01-2026.12

2. 山东省泰山学者青年专家项目，75万，主持，2023.01-2025.12

3. 国家自然科学基金青年项目，30万，主持，2023.01-2025.12

4. 山东省海外优青项目，60万，主持，2022.04-2025.03

l 发表论文

      1. Yijie Wang^#, Xiong Liu^#, Min Wang, Yu Wang, Shuo Wang, Lai Jin, Min Liu, Jun Zhou, Yan Chen^*. UBE3B promotes breast cancer progression by antagonizing HIF-2α degradation. Oncogene. 2023; 42(46): 3394–3406.

      2. Yijie Wang, Yan Chen, Chenliang Wang, Mingming Yang, Yanan Wang, Lei Bao, Jennifer E. Wang, BongWoo Kim, Kara Y. Chen, Weizhi Xu, Emmanuela Capota, Janice Ortega, Deepak Nijhawan, Guo-min Li, Weibo Luo, Yingfei Wang^*. MIF is a 3' flap nuclease that facilitates DNA replication and promotes tumor growth. Nature Communications. 2021; 12(1): 2954.

      3. Yijie Wang^#, Yan Chen^#, Lei Bao, Bo Zhang, Jennifer E. Wang, Ashwani Kumar, Chao Xing, Yingfei Wang^*, Weibo Luo^*. CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors. Cancer Research. 2020; 80(18): 3880-3891.

      4. Yijie Wang^#, Xiong Liu^#, Weixiao Huang^#, Junjie Liang, Yan Chen^*. The intricate interplay between HIFs, ROS, and the ubiquitin system in the tumor hypoxic environment. Pharmacology & Therapeutics. 2022; 240:108303.

      5. Yijie Wang^#, Guangqiang Li^#, Mingxia Deng, Xiong Liu, Weixiao Huang, Yao Zhang, Min Liu, Yan Chen^*. The multifaceted functions of RNA helicases in the adaptive cellular response to hypoxia: From mechanisms to therapeutics. Pharmacology & Therapeutics. 2021; 221: 107783.

      6. Yan Chen^*, Min Liu, Yanling Niu, Yijie Wang^*. Romance of the three kingdoms in hypoxia: HIFs, epigenetic regulators, and chromatin reprogramming. Cancer Letters. 2020; 495: 211-223.

      7. Yijie Wang, Weibo Luo*, Yingfei Wang^*. PARP-1 and its associated nucleases in DNA damage response. DNA Repair. 2019; 81: 102651.

      8. Ji Cao^#, Yijie Wang^#, Rong Dong, Guanyu Lin, Ning Zhang, Jing Wang, Ling Ding, Qiaojun He, Bo Yang^*. Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells. Cancer Research. 2015; 75(22): 4839-51.

      9. Weixiao Huang^#, Xiong Liu^#, Yao Zhang^#, Mingxia Deng, Guangqiang Li, Guo Chen, Li Yu, Lai Jin, Tongzheng Liu*, Yijie Wang^*, Yan Chen^*. USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2α. Journal of Cellular Physiology. 2022; 237(4): 2211-2219.

l 获得奖项

1. 海外引才计划项目获得者 2024

2. 山东省泰山学者青年专家 2023

3. 山东省海外优青 2022

4. 研究生国家奖学金 2016

l 联系方式

  邮箱：yijiewang@sdnu.edu.cn

  地址：山东省济南市长清区555000Jc线路检测中心549