教育经历：

2012.09.01-2015.06.30  555000Jc线路检测中心 博士

2007.09.01-2010.06.30  555000Jc线路检测中心 硕士

2002.09.01-2006.06.30  555000Jc线路检测中心 学士

工作经历：

   2024.01-至今，555000Jc线路检测中心，教授

2018.01-2023.12，555000Jc线路检测中心，副教授

2015.09-2017.12，555000Jc线路检测中心，讲师

2010.07.12-2012.08.31  中国科学院上海巴斯德研究所 科研助理

研究兴趣，领域：

1、鱼类天然免疫模式识别受体的克隆鉴定和功能研究

2、小鼠炎症性肠炎和肠癌的发病机制研究

开设课程：

本科：分子生物学、分子生物学实验

研究生：专业外语（细胞生物学专业）

主持或参加科研项目及人才计划项目情况：

1. NLRP3炎症小体在乳腺癌细胞中的激活及其在PI3K-Akt信号通路介导的癌细胞浸润转移中的作用研究，ZR2017BC073，山东省自然科学基金，2017.08-2019.12，主持。

2. NLRP3在PI3K-Akt信号通路介导的乳腺癌细胞浸润转移中的抑制作用研究，J16LE07，山东省高等学校科技计划项目，2017.01-2018.12，主持。

3. 黄鳝抗细菌病感染的免疫学基础, 2018YFD0900302，国家重点研发计划子课题，2018.12-2022.12，参与。

代表性论文：

1. Zhu Y^#, Shan S^#, Feng H, Jiang L, An L, Yang G*, Li H*, Molecular characterization and functional analysis of interferon regulatory factor 9 (irf9) in common carp Cyprinus carpio: a pivotal molecule in the Ifn response against pathogens. J Fish Biol. 2019, 95(2):510-519. (*corresponding author, IF 2.038)

2. Miao Yin, Ying Zhang, Hua Li*, Advances in Research on Immunoregulation of Macrophages by Plant Polysaccharides, Frontiers in Immunology, 2019, 10: 145. (*corresponding author, IF 4.716)

3. Ting Li^#, Lei Wang^#, Yonghuan Zhang, Xinyi Guo, Xinze Chen, Fumiao Zhang, Guiwen Yang, Wujun Wen* and Hua Li*, Molecular characterization of three novel perforins in common carp (Cyprinus carpio L.) and their expression patterns during larvae ontogeny and in response to immune challenges, BMC Veterinary Research, 2018, 14: 299. (*corresponding author, IF 1.792)

4. Hua Li^#, Ting Li^#, Yujie Guo, Yujun Li, Yan Zhang, Na Teng, Fumiao Zhang* and Guiwen Yang*, Molecular characterization and expression patterns of a non-mammalian toll-like receptor gene (TLR21) in larvae ontogeny of common carp (Cyprinus carpio L.) and upon immune stimulation, BMC Veterinary Research, 2018, 14:153 (IF 1.792)

5. Shijuan Shan^#, Dezhi Liu^#, Rongrong Liu, Yaoyao Zhu, Ting Li, Fumiao Zhang, Liguo An, Guiwen Yang*, Hua Li*, Non-mammalian Toll-like receptor 18 (Tlr18) recognizes bacterial pathogens in common carp (Cyprinus carpio L.):Indications for a role of participation in the NF-κB signaling pathway, Fish& Shellfish Immunology, 2018.1, 72: 187-198. (*corresponding author, IF 3.298)

6. Cong Xu^#, Hua Li^#, Miao Yin, Tao Yang, Liguo An* and Guiwen Yang*, Osteopontin is involved in TLR4 pathway contributing to ovarian cancer cell proliferation and metastasis, Oncotarget, 2017, 8(58): 98394-98404. (^#co-first author)

7. Hua Li^#, Guiwen Yang^#, Fei Ma, Ting Li, Huiting Yang, JH Rombout, Liguo An*, Molecular characterization of a fish-specific toll-like receptor 22 (TLR22) gene from common carp (Cyprinus carpio L.): Evolutionary relationship and induced expression upon immune stimulants. Fish& Shellfish Immunology, 2017, 63: 74-86. (IF 3.185)

8. Ting Li^#, Hua Li^#, Shaoqing Peng, Fumiao Zhang, Liguo An*, Guiwen Yang*. Molecular characterization and expression pattern of X box-binding protein-1 (XBP1) in common carp (Cyprinus carpio L.): Indications for a role of XBP1 in antibacterial and antiviral immunity. Fish& Shellfish Immunology, 2017, 67: 667-674. (^#co-first author, IF 3.185)

9. Ailing Lu^#, Hua Li^#, Junling Niu, Shuxian Wu, Guang Xue, Xiaomin Yao, Qiuhong Guo, Nianhong Wan, Paride Abliz, Guiwen Yang, Liguo An*, Guangxun Meng*, Hyperactivation of the NLRP3 Inflammasome in Myeloid Cells Leads to Severe Organ Damage in Experimental Lupus, The Journal of Immunology, 2017, 198 (3): 1119-1129. (^#co-first author, IF 4.539)

10. Hua Li^#, Hongyan Guo^#, Shijuan Shan, Chenchen Qi, Liguo An, Guiwen Yang. Characterization and expression pattern of a novel β-defensin in common carp (Cyprinus carpio L.): implication for the role in mucosal immunity. Bioscience, Biotechnology, and Biochemistry, 2014, 78 (3): 430-437. (IF 1.206)

11. Liming Mao^#, Liping Zhang^#, Hua Li^#, Wei Chen，Hongbin Wang，Shuxian Wu，Caiqin Guo，Ailing Lu，Guiwen Yang，Liguo An，Paride Abliz and Guangxun Meng. Pathogenic Fungus Microsporum canis Activates the NLRP3 Inflammasome. Infection and Immunity, 2014, 82 (2): 882-892. (^#co-first author, IF 4.156)

12. Hua Li^#, Fumiao Zhang^#, Hongyan Guo, Yaoyao Zhu, Jinduo Yuan, Guiwen Yang, Liguo An. Molecular Characterization of Hepcidin Gene in Common Carp (Cyprinus carpio L.) and Its Expression Pattern Responding to Bacterial Challenge. Fish & Shellfish Immunology, 2013, 35 (3): 1030-1038. (IF 3.034)

13. Hua Li^#, Shuxian Wu^#, Liming Mao^#, Guowei Lei, Liping Zhang, Ailing Lu, Liguo An, Guiwen Yang, Paride Abliz, Guangxun Meng. Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome. Protein & Cell, 2013, 4 (7): 529-538. (IF 2.851)

14. Guowei Lei^#, Mingkuan Chen^#, Hua Li^#, Jun-Ling Niu, Shuxian Wu, Liming Mao, Ailing Lu, Hongbin Wang, Wei Chen, Bin Xu, Qibin Leng, Cunshuan Xu, Guiwen Yang, Liguo An, Li-Ping Zhu, Guangxun Meng. Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome. Cell research, 2013, 23 (7): 965-968. (^#co-first author, IF 11.981)

15. Yongfen Xu^#, Hua Li^#, Wei Chen^#, Xiaomin Yao, Yue Xing, Xun Wang, Jin Zhong, Guangxun Meng. Mycoplasma hyorhinis Activates the NLRP3 Inflammasome and Promotes Migration and Invasion of Gastric Cancer Cells. PLoS ONE, 2013, 8(11): e77955. (^#co-first authors, IF 3.534)

荣誉、奖励及参加学术团体的情况：

　 山东动物学会，理事

　　中国细胞生物学学会，会员

　　山东细胞生物学学会，会员