姓名职称：

杜欣，汉族，教授，博士生导师

教育经历：

2007/09-2011/07555000Jc线路检测中心，生物系，本科，生物科学专业。

2011/09-2016/07南开大学，555000Jc线路检测中心，博士，生物化学与分子生物学专业

工作经历：

2016/08-2020.12 555000Jc线路检测中心，555000Jc线路检测中心，职位：讲师。

2021.01-至今  555000Jc线路检测中心，555000Jc线路检测中心，职位：教授。

研究兴趣，领域：

1、利用电化学传感技术对细胞生物学过程、细胞分泌物、微环境等检测。

2、开发用于疾病标志物、食品功能因子、食品危害物等检测的电化学生物传感器。

3、电化学微流控、可穿戴设备等新型传感装置的开发、纳米材料的合成及其应用。

开设课程：

本科：生物化学、食品生物化学、食品生物化学实验、生物课件制作

主持或参加科研项目及人才计划项目情况：

1、国家自然基金面上项目：基于PD-L1免疫检查点构建用于肿瘤治疗评估的电化学传感系统，起止年月：2022/01-2025/12，在研，主持

2、山东省青年科技人才托举工程：2022/01-2024/12，在研，主持

3、国家自然基金青年基金：用于上皮-间充质转化研究的电化学生物传感系统的建立，起止年月：2019/01-2021/12，在研，主持

4、山东省自然科学基金博士基金：通过检测肿瘤细胞及标志物实现肿瘤早期诊断的生物传感系统的建立，起止年月：2017/06-2019/6，结题，主持

5、中国博士后科学基金面上项目：用于胰腺癌早期诊断的生物传感系统的构建及应用研究，起止年月：2017/06-2018/7，结题，主持

代表性论文：

(1) Xin Du, Zhenhua Zhang, Xiaodi Zheng, Hongyan Zhang, Dan Dong, Zhenguo Zhang, Min Liu, Jun Zhou. An electrochemical biosensor for the detection of epithelial-mesenchymal transition. Nature Communications, 2020, 11: 192.

(2) Xin Du (*), Yuyang Li, Zhenguo Zhang, Congcong Zhang, Jinchun Hu, Xiuxiu Wang, Renshuai Zhang, Jilong Yang, Lei Zhou, Hongyan Zhang, Min Liu, Jun Zhou(**). An electrochemical biosensor for the assessment of tumor immunotherapy based on the detection of immune checkpoint protein programmed death ligand-1Biosensors and Bioelectronics, 207 (2022) 114166.

(3) Zhang Congcong, Liu Lisheng, Li Hua, Hu Jinchun, Zhang Jiancheng, Zhou Han, Zhang Zhenguo*, Du Xin*. An oriented Antibody immobilization based electrochemical platform for detection of Leptin in human with different body mass index. Sensors and Actuators B: Chemical. 2022,2 (353).

(4) Jinchun Hu, Zhenguo Zhang, Congcong Zhang, Jiancheng Zhang, Han Zhou, Fansheng Ning, Daijie Wang*, Xin Du*. Ginsenoside Rg3 determination using an electro-synthesized molecularly imprinted polymer on MWCNT-Ti3C2Tx nanocomposite modified electrode. Talanta,15 March 2022, 123391.

(5) Du, Xin; Miao, Zhiying; Zhang, Di; Fang, Yuxin; Ma, Min; Chen, Qiang (*). Facile synthesis of beta-lactoglobulin-functionalized multi-wall carbon nanotubes and gold nanoparticles on glassy carbon electrode for electrochemical sensing. Biosensors and Bioelectronics, 2014.12.15, 62: 73~78.

(6) Du, Xin; Zhang, Zhenguo; Miao, Zhiying; Ma, Min; Zhang, Yanyan; Zhang,Cong; Wang, Weizhen; Han, Bingkai; Chen, Qiang (*). One step electrodeposition of dendritic gold nanostructures on beta-lactoglobulin-functionalized reduced graphene oxide for glucose sensing, Talanta, 2015.11.1, 144: 823~829.

(7) Du, Xin; Chen, Yuan; Dong, Wenhao; Han, Bingkai; Liu, Min; Chen, Qiang (*); Zhou, Jun (*). A nanocomposite-based electrochemical sensor for non-enzymatic detection of hydrogen peroxide, Oncotarget, 2016.12.27, 8(8): 13039~13047.

(8) Du, Xin ^(#) ; Zhang, Zhenguo ^(#) ; Zhang, Cong; Zhang, Yanyan; Chen, Qiang (*). One-step electrodeposition of poly (3,4-ethylenedioxythiophene) on carboxylated multi-wall carbon nanotubes and its application in ascorbic acid sensing, Journal of Electroanalytical Chemistry, 2016.12.1, 782: 84~90.

(9) Du, Xin*, Jun Zhou. Application of biosensors to detection of epidemic diseases in animals. Research in Veterinary Science 118 (2018) 444–448.

(10) Xin Du, Xiaodi Zheng, Zhenhua Zhang, Xiaofan Wu, Lei Sun, Jun Zhou, Min Liu. A label-free electrochemical immunosensor for detection of the tumor marker CA242 based on reduced graphene oxide-gold-palladium nanocomposite. Nanomaterials, 2019, 9(9): 1335.

(11) Zhenguo Zhang, Jun Zhou and Xin Du*. Electrochemical Biosensors for Detection of Foodborne Pathogens. Micromachines 2019, 10, 222.

(12) Zhenguo Zhang, Yulin Cong, Yichun Huang and Xin Du*. Nanomaterials-based Electrochemical Immunosensors. Micromachines 2019, 10, 397.

(13) Application of electrochemical biosensors in tumor cell Detection; Zhenhua Zhang, Qingchao Li, Xin Du*, Min Liu *. Thoracic Cancer, 2020, 1759-7706.

(14) Zhang Congcong and Du Xin*. Electrochemical Sensors Based on Carbon Nanomaterial Used in Diagnosing Metabolic Disease. Front. Chem.

(15) Jinchun Hu, Congcong Zhang, Xue Li and Du Xin*. An Electrochemical Sensor Based on Chalcogenide Molybdenum Disulfide-Gold-Silver Nanocomposite for Detection of Hydrogen Peroxide Released by Cancer Cells. Sensors 2020, 20, 6817.

(16) Liu, Min; Du Xin; Zhou, Jun*. Non-canonical function of Tat in regulating host microtubule dynamics: Implications for the pathogenesis of lentiviral infections , Pharmacol Ther, 2018.2, 182: 28~32.

授权专利：

周军，杜欣，张振华。一种基于石墨烯-金-钯纳米复合材料的胰腺癌肿瘤标志物免疫传感器的制备，中国发明专利，专利号ZL 2018 1 0654087.2。

获奖等情况

1、省级教学比赛奖。2020年获山东省 “超星杯”高校青年教师教学比赛优秀奖。

2、优秀学士毕业论文指导教师。

联系方式：

555000Jc线路检测中心（长清湖校区）博物楼303室，邮箱：xdu@sdnu.edu.cn