刘敏

日期: 2017/04/24 作者: 浏览量:


 

刘敏

姓名职称:

刘敏教授,博士生导师

 

教育经历:

1994/09-1998/07山东农业大学,资源与环境学院,学士

1998/09-2001/07山东农业大学,555000Jc线路检测中心,硕士。

2006/09-2009/07南开大学,555000Jc线路检测中心,博士,遗传学专业,导师:李明刚教授。

 

工作经历:

2015/11-至今 555000Jc线路检测中心,教授、博士生导师

2010/09-2015/10 天津医科大学基础医学院,副教授

2005/09-2010/08 南开大学555000Jc线路检测中心

2002/09-2005/11 美国Emory大学医学院

 

研究兴趣,领域:

研究方向:细胞增殖调控;肿瘤与免疫疾病

 

主持或参加科研项目及人才计划项目情况:

1. 国家自然科学基金面上项目, OFIP调节有丝分裂纺锤体定向的机制与功能,2019/01-2022/1260万元,主持

2. 国家自然科学基金应急管理项目,人类免疫缺陷病毒Tat蛋白的泛素化修饰与功能调控,2018/01-2018/1215万元,主持

3. 国家自然科学基金面上项目,有丝分裂驱动蛋白Eg5的活性、定位和功能的调控,2017/01-2020/1264万元,主持

4. 国家自然科学基金面上项目, EB1/CYLD互作对微管动态性及细胞分裂和迁移的调控,2013/01-2016/1280万元,主持

 

代表性论文:

1. Chen M, Wang J, Yang Y, Zhong T, Zhou P, Ma H, Li J, Li D, Zhou J, Xie S*, Liu M*. Redox-dependent regulation of end-binding protein 1 activity by glutathionylation. Sci China Life Sci. 2020. doi: 10.1007/s11427-020-1765-6

2. Ran J, Liu M*, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X, Zhou J*. ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia. Dev Cell. 2020;53(3):287-299.e5

3. Du X, Zhang Z, Zheng X, Zhang H, Dong D, Zhang Z, Liu M*, Zhou J*. An electrochemical biosensor for the detection of epithelial-mesenchymal transition. Nat Commun. 2020;11(1):192.

4. Xie S*, Wu Y, Hao H, Li J, Guo S, Xie W, Li D, Zhou J, Gao J, Liu M*. (2019). CYLD deficiency promotes pancreatic cancer development by causing mitotic defects. Journal of Cellular Physiology234(6):9723-9732.

5. Li J, Liu M*. (2019). Biological features and regulatory mechanisms of salt tolerance in plants. Journal of Cellular Biochemistry120:10914-10920

6. Liu M, Du X, Zhou J. (2018). Non-canonical function of Tat in regulating host microtubule dynamics: implications for the pathogenesis of lentiviral infections.Pharmacology & Therapeutics182:28-32.

7. Xie S, Yang Y, Lin X, Zhou J, Li D, Liu M*. (2018). Characterization of a novel EB1 acetylation site important for the regulation of microtubule dynamics and cargo recruitment.Journal of Cellular Physiology 233(3):2581-2589.

8. Liu M*, Ran J, Zhou J. (2018). Non-canonical functions of the mitotic kinesin Eg5. Thoracic Cancer9(8):904-910.

9. Chen M, Li Y, Liu Z, Qu Y, Zhang H, Li D, Zhou J, Xie S*, Liu M*. (2018). Exopolysaccharidesfrom a Codonopsispilosula endophyte activate macrophages and inhibit cancer cell proliferation and migration. Thoracic Cancer 9(5):630-639.

10. Liu M, Xie S, Zhou J. (2018). Use of animal models for the imaging and quantification of angiogenesis. Experimental Animals67(1):1-6.

11. Shi X*, Li D, Wang Y, Liu S, Qin J, Wang J, Ran J, Zhang Y, Huang Q, Liu X, Zhou J, Liu M*. (2017). Discovery of centrosomal protein 70 as an important player in the development and progression of breast cancer. American Journal of Pathology187(3):679-688.

12. Shi X*, Wang Y, Sun X, Wang C, Jiang P, Zhang Y, Liu X, Li D, Zhou J, Liu M*. (2017). Centrosomal protein 70 regulates paclitaxel sensitivity by promoting microtubule assembly. International Journal of Molecular Sciences 18(6).

13. Yang Y, Mu T, Li T, Xie S, Zhou J, Liu M*, Li D*. (2017). Effects of FSTL1 on the proliferation and motility of breast cancer cells and vascular endothelial cells. Thoracic Cancer 8(6):606-612.

 

联系方式:

山东省济南市历下区文化东路88号555000Jc线路检测中心实验大楼406室(邮编250014);电话:0531-86182516;邮箱:minliu@sdnu.edu.cn