教育经历：

1981-1985 555000Jc线路检测中心生物系，本科生

1985-1988 555000Jc线路检测中心生物系，动物学 硕士研究生

1997-2000  中国科学院海洋研究所，海洋生物 博士研究生

工作经历：

1987-2001 555000Jc线路检测中心 生物系，助教、讲师、副教授

2001-2003 Post-doctoral Research Associate, Kumamoto University, Japan

2003-2004 555000Jc线路检测中心 555000Jc线路检测中心，教授

2004-2009 Visiting Fellow, National Cancer Institute, National Institutes of Health, USA

2009-2013 555000Jc线路检测中心 555000Jc线路检测中心，教授、博士生导师

2013-2014 Visiting Fellow, Warwick University, UK

2014-至今 555000Jc线路检测中心 555000Jc线路检测中心，教授、博士生导师

研究兴趣、领域：

1、抗癌药物抑制癌细胞增殖和迁移的信号转导通路研究

2、抗衰老药物延缓硬骨鱼衰老延长寿命的作用机理研究

开设课程：

《发育生物学》、《现代发育生物学》

代表性论文：

1. Wei JT, Qi H, Liu KK, Zhao CS, Bian Y, Li GR*. Effects of Metformin on Life Span, Cognitive Ability, and Inflammatory Response in a Short-Lived Fish. J Gerontol A Biol Sci Med Sci. 2020, glaa109.

2. Zheng ZD, Bian Y, Zhang Y, Ren GH, Li GR*. Metformin Activates AMPK/SIRT1/NF-κB Pathway and Induces Mitochondrial Dysfunction to Drive caspase3/GSDME-mediated Cancer Cell Pyroptosis.. Cell Cycle. 2020, 19(10):1089-1104.

3. Bian Y, Wei JD, Zhao CS, Li GR*. Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer. Int J Mol Sci. 2020, 21(2). pii: E684.

4. Zheng ZD, Li GR*. Mechanisms and Therapeutic Regulation of Pyroptosis in Inflammatory Diseases and Cancer. Int J Mol Sci. 2020, 21(4). pii: E1456.

5. Zhang Y, Li GR*. A tumor suppressor DLC1: The functions and signal pathways. J Cell Physiol. 2020, 235(6):4999-5007. doi: 10.1002/jcp.29402. Epub 2019 Nov 26.

6. Liu S, Zheng Z, Ji S; Liu T, Hou Y, Li S, Li GR*. Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri. Fish and Shellfish Immunology.80:473-479, 2018.

7. Ji S,, Zheng Z, Liu S, Ren G, Gao J, Zhang Y, Li GR*.  Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. Exp Cell Res. 370(2):292-302, 2018.

8. Liu T, Liu S, Ma L, Li F, Zheng Z, Chai R, Hou Y, Xie Y, Li GR*, Oogenesis, vitellogenin-mediated ovarian degeneration and immune response in the annual fish Nothobranchius guentheri. Fish & Shellfish Immunology 66: 86-92. 2017

9. Liu T, Ma L, Zheng Z, Li F, Liu S, Xie Y, Li GR*. Resveratrol inhibits age-dependent     spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fsh Nothobranchius guentheri. Oncotarget 8(33):55422-55434. 2017.

10. Yang B, Zhu W, Zheng Z, Chai R, Ji S, Ren G, Liu T, Liu Z, Song T, Li F, Liu S, Li GR*, Fluctuation of ROS regulates proliferation and mediates inhibition of migration by reducing the interaction between DLC1 and CAV-1 in breast cancer cells. In Vitro Cell Dev Biol Anim. 53(4):354-362. 2017            

11. Zhu W, Ma L, Yang B, Zheng Z, Chai R, Liu T, Liu Z, Song T, Li F, Li GR* Flavone inhibits migration through DLC1/RhoA pathway by decreasing ROS generation in breast cancer cells. In Vitro Cell Dev Biol Anim. 52(5):589-97. 2016

12. Liu T, Qi H, Ma L, Liu Z, Fu H, Zhu W, Song T, Yang B, Li GR*. Resveratrol attenuates oxidative stress and extends lifespan in the annual fish Nothobranchius Guentheri. Rejuvenation Res. 18(3):225-33. 2015

13. Zhu W, Yang B, Fu H, Ma L, Liu T, Chai R, Zheng Z, Zhang Q, Li GR*. Flavone inhibits nitric oxide synthase (NOS) activity, nitric oxide production and protein S-nitrosylation in breast cancer cells. Biochemical and Biophysical Research Communications (BBRC). 458:590-595. 2015

14. Ma L, Zhu W, Liu T, Fu H, Liu Z, Yang B, Song T, Li GR*, H₂O₂ Inhibits Proliferation and Mediates Suppression of Migration via DLC1/RhoA Signaling in Cancer Cells. Asian Pac J Cancer Prev. 16(4):1637-42. 2015.

15. Yu X, Li GR*. Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fishNothobranchiusguentheri. Exp Gerontol. 47:940-949. 2012.

16. Li GR^#, Du XL, Vass W, Papageorge A, Lowy DR* Qian X*. Full activity of the deleted in liver cancer1(DLC1)tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase(FAK). Proc Natl Acad Sci U S A (PNAS). 108(41):17129-17134. 2011.

17. Qian X, Li GR, Vass WC, Papageorge AG, Walker R, Asnaghi L, Steinbach PJ, Tosato G, Hunter K, Lowy DR*. The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis. CANCER CELL; 16(3):246-58. 2009.

18. Qian X#, Li GR#, Asmussen HK, Asnaghi L, Vass WC, Braverman R, Yamada KM, Popescu NC, Papageorge AG, Lowy DR. Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Proc Natl Acad Sci U S A. 104(21):9012-7. 2007

主持和参与的研究课题:

1.国家自然科学基金项目：白藜芦醇通过SIRT1抑制假鳃自发肝脏肿瘤的作用及其表观遗传调控机制 （31672377），主持。

2．国家自然科学基金项目：白藜芦醇通过SIRT1 抑制肿瘤发生延缓贡氏假鳃鳉衰老的机理研究（31340035），主持。

3．山东省科技重大专项（重大关键技术）项目，肿瘤靶向药物筛选关键技术研究（项目编号2015ZDJS04003），第二位。

4．山东省自然科学基金重点项目：活性氧H2O2在乳腺癌细胞中调节RhoA活性的信号转导通路及作用机理研究（ZR2013CZ002） ，主持。

5. 山东省科技发展计划项目:黄酮抑制乳腺癌增殖和迁移的研究 (2012CSF12112) ，主持。

6. 山东省自然科学基金项目: 肿瘤抑制基因DLC-1通过talin的抑癌作用机理 ( ZR2009DM048) ，主持。

荣誉、奖励及参加学术团体的情况：

2015年 获555000Jc线路检测中心优秀教学奖

2018年 山东省优秀博士学位论文指导教师

2019年 山东省优秀研究生指导教师

中国动物学会动物生理生态学分会委员、山东动物学会常务理事、山东细胞生物学会理事、

联系方式：

济南市文化东路88号 555000Jc线路检测中心 555000Jc线路检测中心（250014）

邮箱：grli@sdnu.edu.cn