姓名职称：

单世娟，副教授，硕士生导师

教育经历：

2006/09-2010/07 齐鲁工业大学，食品与生物工程学院，本科，生物技术专业。

2011/09-2014/06555000Jc线路检测中心，555000Jc线路检测中心，硕士，细胞生物学专业，导师：杨桂文教授。

2014/09-2017/07555000Jc线路检测中心，555000Jc线路检测中心，博士，动物学专业，导师：安利国教授

工作经历：

2017/09-2020/12 555000Jc线路检测中心，555000Jc线路检测中心，讲师。

2021/01-至今 555000Jc线路检测中心，555000Jc线路检测中心，副教授。

研究兴趣，领域：

利用细胞生物学、分子生物学及免疫学等技术，开展鱼类病原体与宿主互作的分子及细胞机理的研究。

开设课程：

本科：细胞工程、免疫学

研究生：动物与植物细胞工程

主持或参加科研项目及人才计划项目情况：

1．鱼类特有的TLR18调控鲤鱼抗菌肽表达的作用机制研究，32002419，国家自然科学基金青年项目，2020/01-2023/12，24万元，主持。

2. 鱼类特异TLR18在鲤鱼抗细菌感染免疫中的作用机制研究，2017M622258，中国博士后科学基金面上资助，2017/11-2019/11，5万元，主持。

3．鱼类特异性模式识别受体TLR18的识别特性和作用机制研究，ZR2018BC054，山东省自然科学基金博士基金，2018/03-2020/12，8万元，主持。

4．黄鳝抗细菌病感染的免疫学基础, 2018YFD0900302，国家重点研发计划子课题，2018.12-2022.12，46万，参与。

5．鲤鱼新型免疫球蛋白IgT粘膜免疫特性及其抗体库多样性研究，31972828，国家自然科学基金面上项目，2020.1-2023.12，56万元，参与。

代表性论文：

1. Rongrong Liu, Hua Li, Xiaoye Liu, Boyu Liang, Yue Qi, Fei Meng, Guiwen Yang, Shijuan Shan, TRIM25 inhibits spring viraemia of carp virus replication by positively regulating RIG-I signaling pathway in common carp (Cyprinus carpio L.), Fish Shellfish Immunol, 2022, 127:306-317.

2. Rongrong Liu, Yue Qi, Hanxiao Feng, Yan Niu, Fumiao Zhang, Guiwen Yang, Shijuan Shan, Fish-specific Toll-like receptor 14 (TLR14) from Asian swamp eel (Monopterus albus) is involved in immune response to bacterial infection, 2022, 124:313-323.

3. Rongrong Liu, Yue Qi, Yaqing Zhai, Hua Li, Liguo An, Guiwen Yang, Shijuan Shan, Identification and functional analysis of Mannose receptor in Asian swamp eel (Monopterus albus) in response to bacterial infection, 2022, 127:463-473.

4. Rongrong Liu, Xiaoye Liu, Meijiao Song, Yue Qi, Hua Li, Guiwen Yang, Shijuan Shan, Cyprinus carpio TRIF Participates in the Innate Immune Response by Inducing NF-κB and IFN Activation and Promoting Apoptosis, Front Immunol, 2021, 12:725150.

5. Shijuan Shan, Rongrong Liu, Hanxiao Feng, Fei Meng, Muhanmmad Aizaz , Guiwen Yang, Identification and functional characterization of a fish-specific tlr19 in common carp (Cyprinus carpio L.) that recruits TRIF as an adaptor and induces ifn expression during the immune response, Vet Res, 2021, 52(1):88.

6. Shijuan Shan, Rongrong Liu, Hanxiao Feng, Yonghuan Zhang, Fumiao Zhang, Cui Lv, Guiwen Yang, Identification and functional characterization of the transcription factor NF-κB subunit p65 in common carp (Cyprinus carpio L.), Fish Shellfish Immunol, 2019, 95:25-34.

7. Shijuan Shan, rongrong Liu, Lei Jiang, Yaoyao Zhu, Hua Li, Weixian Xing, Guiwen Yang, Carp Toll-like receptor 8 (Tlr8): An intracellular Tlr that recruits TIRAP as adaptor and activates AP-1 pathway in immune response, Fish & Shellfish Immunology, 2018, 82:41-49

8. Shijuan Shan, Dezhi Liu, Rongrong Liu, Yaoyao Zhu, Ting Li, Fumiao Zhang, Liguo An, Guiwen Yang, Hua Li, Non-mammalian Toll-like receptor 18 (Tlr18) recognizes bacterial pathogens in common carp (Cyprinus carpio L.): Indications for a role of participation in the NF-κB signaling pathway, Fish & Shellfish Immunology, 2018, 72: 187-198.

9. Shijuan Shan, Chenchen Qi, Yaoyao Zhu, Hua Li,Liguo An^*, Guiwen Yang^*.Expression profile of carp IFN correlate with the up-regulation of interferonregulatory factor-1 (IRF-1)in vivo andin vitro: the pivotal molecules in antiviral defense, Fish & Shellfish Immunology, 2016, 52: 94-102.

10. Shijuan Shan, Dezhi Liu, Lei Wang, Yaoyao Zhu, Fumiao Zhang, Ting Li, Liguo An^*and Guiwen Yang^*. Identification and expression analysis ofirak1 gene in common carp Cyprinus carpio L.: indications for a role of antibacterial and antiviral immunity. Journal of Fish Biology, 2015, 87: 241–255.

11. Yaoyao Zhu, Shijuan Shan, Huaping Zhao, Rongrong Liu, Hui Wang, Xinping Chen, Guiwen Yang, Hua Li, Identification of an IRF10 gene in common carp (Cyprinus carpio L.) and analysis of its function in the antiviral and antibacterial immune response, BMC Veterinary Research, 2020,16(1):450.

12. Fumiao Zhang, Shijuan Shan, Xiaoyang Xu, Yao Wang, Yonghuan Zhang, Miao Yin, Guiwen Yang, Molecular characterization and expression analysis of two peptidoglycan recognition proteins (CcPGRP5, CcPGRP6) in larvae ontogeny of common carp Cyprinus carpio L. and upon immune stimulation by bacteria, BMC Vet Res, 2019, 15(1):10.

13. Yaoyao Zhu, Shijuan Shan, Hanxiao Feng, Lei Jiang, Liguo An, Guiwen Yang, Hua Li, Molecular characterization and functional analysis of interferon regulatory factor 9 (irf9) in common carp Cyprinus carpio: a pivotal molecule in the Ifn response against pathogens, J Fish Biol, 2019, 95(2):510-519.

获奖等情况:

1. 校级优秀硕士学位毕业论文指导教师。

联系方式

邮箱：shansj@sdnu.edu.cn